期刊名：Toxics

期刊主页：https://www.mdpi.com/journal/toxics

本期文献清单，为您精选 Toxics 期刊“药物毒性”方向的高质量研究论文。这些文章涵盖从毒理机制解析（如 ROS 介导的未折叠蛋白反应、Wnt/β-连环蛋白信号通路）到临床特征分析（如甲醇暴露、乙胺丁醇视神经病变、乙烯利中毒），从新型预测技术（人工智能驱动的毒性预测）到特定药物的综合评估（芬太尼、氯胺酮、阿霉素心脏毒性等），力求为药物毒理学、临床药学、法医学及公共卫生领域的研究者与实践者提供前沿的学术洞察与有价值的解决方案参考，助力您在药物毒性风险评估与中毒防治研究中开拓新思路、取得新进展。

1. The Perils of Methanol Exposure: Insights into Toxicity and Clinical Management

甲醇暴露的危险：毒性机制与临床管理解析

https://www.mdpi.com/2305-6304/12/12/924

Alrashed, M.; Aldeghaither, N.S.; Almutairi, S.Y.; Almutairi, M.; Alghamdi, A.; Alqahtani, T.; Almojathel, G.H.; Alnassar, N.A.; Alghadeer, S.M.; Alshehri, A.; et al. The Perils of Methanol Exposure: Insights into Toxicity and Clinical Management. Toxics 2024, 12, 924. https://doi.org/10.3390/toxics12120924.

2. Artificial Intelligence-Driven Drug Toxicity Prediction: Advances, Challenges, and Future Directions

人工智能驱动的药物毒性预测：进展、挑战与未来方向

https://www.mdpi.com/2305-6304/13/7/525

Zhang, R.; Wen, H.; Lin, Z.; Li, B.; Zhou, X. Artificial Intelligence-Driven Drug Toxicity Prediction: Advances, Challenges, and Future Directions. Toxics 2025, 13, 525. https://doi.org/10.3390/toxics13070525.

3. Pathophysiology of Doxorubicin-Mediated Cardiotoxicity

阿霉素介导的心脏毒性的病理生理学

https://www.mdpi.com/2305-6304/13/4/277

Arrigoni, R.; Jirillo, E.; Caiati, C. Pathophysiology of Doxorubicin-Mediated Cardiotoxicity. Toxics 2025, 13, 277. https://doi.org/10.3390/toxics13040277.

4. Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths

CYP2D6、2C19和3A4表型转换在药物相关死亡中的作用

https://www.mdpi.com/2305-6304/12/4/260

Aly, S.M.; Hennart, B.; Gaulier, J.-M.; Allorge, D. Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths. Toxics 2024, 12, 260. https://doi.org/10.3390/toxics12040260.

5. A Review of Toxicological Profile of Fentanyl—A 2024 Update

芬太尼毒理学特征综述——2024年更新版

https://www.mdpi.com/2305-6304/12/10/690

Williamson, J.; Kermanizadeh, A. A Review of Toxicological Profile of Fentanyl—A 2024 Update. Toxics 2024, 12, 690. https://doi.org/10.3390/toxics12100690.

6. Study on the Distribution Characteristics and Risk Assessment of Antibiotics and Resistance Genes in Water Sources of Wuhan

武汉市水源中抗生素和抗性基因的分布特征及风险评估研究

https://www.mdpi.com/2305-6304/12/7/507

Wang, J.; Yu, Y.; Jiang, J.; Li, B.; Xie, W.; Li, G.; Song, H.; Zhai, W.; Li, Y. Study on the Distribution Characteristics and Risk Assessment of Antibiotics and Resistance Genes in Water Sources of Wuhan. Toxics 2024, 12, 507. https://doi.org/10.3390/toxics12070507.

7. Integrating Epigenetics, Proteomics, and Metabolomics to Reveal the Involvement of Wnt/β-Catenin Signaling Pathway in Oridonin-Induced Reproductive Toxicity

整合表观遗传学、蛋白质组学和代谢组学揭示Wnt/β-连环蛋白信号通路参与冬凌草甲素诱导的生殖毒性

https://www.mdpi.com/2305-6304/12/5/339

Wu, Q.; Gao, X.; Lin, Y.; Wu, C.; Zhang, J.; Chen, M.; Wen, J.; Wu, Y.; Tian, K.; Bao, W.; et al. Integrating Epigenetics, Proteomics, and Metabolomics to Reveal the Involvement of Wnt/β-Catenin Signaling Pathway in Oridonin-Induced Reproductive Toxicity. Toxics 2024, 12, 339. https://doi.org/10.3390/toxics12050339.

8. Comparative Analysis of Therapeutic Efficacy and Adverse Reactions among Various Thrombolytic Agents

不同溶栓药物的疗效及不良反应比较分析

https://www.mdpi.com/2305-6304/12/7/458

Xie, C.; Zheng, N.; Li, M.; Zhang, Z.; Huang, D.; Xiao, M.; Chen, D.; He, C.; Zuo, Z.; Chen, X. Comparative Analysis of Therapeutic Efficacy and Adverse Reactions among Various Thrombolytic Agents. Toxics 2024, 12, 458. https://doi.org/10.3390/toxics12070458.

9. Risk Factors of Optic Neuropathy in Ethambutol Users: Interaction with Isoniazid and Other Associated Conditions of Toxic Optic Neuropathy

乙胺丁醇使用者视神经病变的危险因素：与异烟肼的相互作用及其他中毒性视神经病变的相关情况

https://www.mdpi.com/2305-6304/12/8/549

Kim, J.; Ahn, S.J. Risk Factors of Optic Neuropathy in Ethambutol Users: Interaction with Isoniazid and Other Associated Conditions of Toxic Optic Neuropathy. Toxics 2024, 12, 549. https://doi.org/10.3390/toxics12080549.

10. What Do We Know About Staphylococcus aureus and Oxidative Stress? Resistance, Virulence, New Targets, and Therapeutic Alternatives

关于金黄色葡萄球菌与氧化应激我们知道什么？耐药性、毒力、新靶点及治疗替代方案

https://www.mdpi.com/2305-6304/13/5/390

Bastos, M.L.C.; Ferreira, G.G.; Kosmiscky, I.d.O.; Guedes, I.M.L.; Muniz, J.A.P.C.; Carneiro, L.A.; Peralta, Í.L.d.C.; Bahia, M.N.M.; Souza, C.d.O.; Dolabela, M.F. What Do We Know About Staphylococcus aureus and Oxidative Stress? Resistance, Virulence, New Targets, and Therapeutic Alternatives. Toxics 2025, 13, 390. https://doi.org/10.3390/toxics13050390.

11. Toxicological Assessment of Ketamine in Juvenile Zebrafish (Danio rerio)

氯胺酮对幼年斑马鱼（Danio rerio）的毒理学评估

https://www.mdpi.com/2305-6304/13/2/82

Tang, Y.; Yang, K.; Xu, J.; Qiu, Y.; Meng, L.; Zhao, S. Toxicological Assessment of Ketamine in Juvenile Zebrafish (Danio rerio). Toxics 2025, 13, 82. https://doi.org/10.3390/toxics13020082.

12. ROS-Mediated Unfolded Protein Response Activation Drives Hepatocyte Apoptosis in Mesaconitine-Induced Liver Injury

ROS介导的未折叠蛋白反应激活驱动美沙乌头碱诱导的肝损伤中的肝细胞凋亡

https://www.mdpi.com/2305-6304/13/3/155

Tian, J.; Zhuang, Y.; Liu, Y.; Zheng, Y.; Liu, X.; Lin, S.; Zheng, C.; Wu, Z. ROS-Mediated Unfolded Protein Response Activation Drives Hepatocyte Apoptosis in Mesaconitine-Induced Liver Injury. Toxics 2025, 13, 155. https://doi.org/10.3390/toxics13030155.

13. The Role of Oxidative Stress in the Pathogenesis and Treatment of Leishmaniasis: Impact on Drug Toxicity and Therapeutic Potential of Natural Products

氧化应激在利什曼病发病机制和治疗中的作用：对药物毒性的影响及天然产物的治疗潜力

https://www.mdpi.com/2305-6304/13/3/190

Brígido, H.P.C.; dos Santos, L.G.A.; de Barros, R.C.; Correa-Barbosa, J.; Santos, P.V.B.d.; Paz, R.F.L.; Pereira, A.R.; Albuquerque, K.C.O.d.; Campos, M.B.; Silveira, F.T.; et al. The Role of Oxidative Stress in the Pathogenesis and Treatment of Leishmaniasis: Impact on Drug Toxicity and Therapeutic Potential of Natural Products. Toxics 2025, 13, 190. https://doi.org/10.3390/toxics13030190.

14. Ethephon Poisoning: Clinical Characteristics and Outcomes

乙烯利中毒：临床特征与结局

https://www.mdpi.com/2305-6304/13/2/115

Trakulsrichai, S.; Chuayaupakarn, K.; Tansuwannarat, P.; Rittilert, P.; Tongpoo, A.; Sriapha, C.; Wananukul, W. Ethephon Poisoning: Clinical Characteristics and Outcomes. Toxics 2025, 13, 115. https://doi.org/10.3390/toxics13020115.

15. Trace Detection of Di-Isopropyl Methyl Phosphonate DIMP, a By-Product, Precursor, and Simulant of Sarin, Using Either Ion Mobility Spectrometry or GC-MS

使用离子迁移谱或气相色谱-质谱联用技术对沙林副产物、前体及模拟剂——甲基膦酸二异丙酯（DIMP）进行痕量检测

https://www.mdpi.com/2305-6304/13/2/102

Bocos-Bintintan, V.; Bocos-Bintintan, P.-F.; Rozsypal, T.; Beldean-Galea, M.S. Trace Detection of Di-Isopropyl Methyl Phosphonate DIMP, a By-Product, Precursor, and Simulant of Sarin, Using Either Ion Mobility Spectrometry or GC-MS. Toxics 2025, 13, 102. https://doi.org/10.3390/toxics13020102.

栏目介绍：Drugs Toxicity 药物毒性

栏目链接：https://www.mdpi.com/journal/toxics/sections/drugs_toxicity

“药物毒性”栏目（Drugs Toxicity Section）专注于研究滥用药物以及药物作用于中枢神经系统和周围神经系统所产生的毒理学效应。本栏目诚邀高质量稿件，关于急性和慢性接触滥用药物及相关药物对中枢神经系统（CNS）和周围神经系统（PNS）影响的研究。滥用药物涵盖酒精、可卡因、甲基苯丙胺、尼古丁、卡西酮、阿片类药物、致幻剂、大麻、摇头丸（MDMA）、LSD、麦司卡林、裸盖菇素、PCP、氟硝西泮（Rohypnol）及其他滥用药物。本栏目同时也欢迎涉及其他中枢神经系统药物的研究投稿，包括苯二氮卓类药物、抗精神病药及其他作用于中枢神经系统的药物。此外，本栏目欢迎采用药理学和实验方法，探讨滥用药物及其他影响中枢神经系统和周围神经系统的药物所致毒理学效应的研究。

栏目主编：本栏目由美国托莱多大学Prof. Dr. Youssef Sari担任栏目主编。Prof. Dr. Youssef Sari主要研究方向为药物滥用对中枢神经和外周系统影响的药理学和毒理学研究；用于治疗药物滥用的药物发现。

Toxics 期刊介绍

期刊名：Toxics (ISSN: 2305-6304)

主编：Demetrio Raldúa, IDAEA-CSIC, Spain

期刊发表与有毒有害化学物质和材料相关的学术文章，主题范围涵盖毒理学、生态毒理学、环境科学、环境工程、环境化学和流行病学等学科。期刊已被Web of Science、PubMed和Scopus等多个数据库收录。目前期刊位于JCR毒理学一区和环境科学二区。