为庆祝Wiley向生命健康与环境科学重点领域进行战略拓展，Advanced Portfolio重磅推出肿瘤学与癌症研究领域线上专题精选合集。本合集涵盖肿瘤自身及其对微环境中的免疫、神经、血管、基质和微生物的可塑性研究和综述，以及对精准癌症治疗最新进展的探讨，展望肿瘤学和癌症研究的未来发展方向。

了解合集或者文章更多详情，欢迎点击链接或扫描二维码：

https://advanced.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)2198-3844.oncology-cancer-research

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

作者：Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde

First published: 27 March 2025

https://doi.org/10.1002/advs.202500296

本综述讨论了 STING 激动剂临床应用所面临的局限性，并由此展望未来研究方向，包括其对肿瘤微环境的影响，以及哪些肿瘤类型可能从该治疗中获益，从而提高临床治疗效果，并克服肿瘤免疫抑制带来的不利影响。

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Cancer-Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

作者：Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang

First published: 28 March 2026

https://doi.org/10.1002/advs.202510043

本综述讨论了癌症相关成纤维细胞（CAFs）在肿瘤微环境中对于胞外基质重塑、免疫抑制、代谢重编程、血管生成、肿瘤耐药性和干细胞特性维持的作用，同时也阐述了具有抑瘤功能的CAF亚群，并评述了CAF靶向治疗策略的应用前景。

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Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro-Ecological Perspective

作者：Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu

First published: 28 June 2026

https://doi.org/10.1002/advs.76248

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Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

作者：Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming-jie Kuang, Xiaoyuan Ji

First published: 09 September 2025

https://doi.org/10.1002/advs.202506813

以上两篇综述讨论了肿瘤神经学的最新进展，强调神经系统在肿瘤进展中的关键作用，包括其对肿瘤微环境的重塑和生物学影响。

Mechanistic Foundations of KRAS-Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

作者：Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai

First published: 09 June 2025

https://doi.org/10.1002/advs.202502714

本综述通过讨论KRAS驱动肿瘤与其微环境中的免疫、代谢、微生物和基质相互作用的生物学机制，来阐述靶向KRAS突变体和肿瘤微环境的崭新治疗方案。

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Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non-Responders to Immunotherapy

作者：Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu

First published: 26 June 2025

https://doi.org/10.1002/advs.202416756

本综述仔细阐明癌症疫苗的设计和疗效评价系统，从而为未来癌症疫苗的发展提供思路。

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Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

作者：Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin-ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara

First published: 23 June 2026

https://doi.org/10.1002/advs.76071

本研究通过胎盘部位滋养细胞肿瘤病人的组织和血液样品，初步发现癌细胞可通过与B细胞发生细胞融合，获得大量可由DNIMA检测到的非遗传性母源基因，提示肿瘤适应性的新机制。

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Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF-1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

作者：Jeong-Eun Yun, Jieun Seo, Jiwon Koh, Seock-Ah Im, Ki Yong Hong, Yeseon Son, Do-Won Jeong, Junji Fukuda, Jong-Wan Park, Yang-Sook Chun

First published: 29 October 2025

https://doi.org/10.1002/advs.202515186

本研究发现肿瘤细胞可通过分泌CCL2，激活邻近脂肪组织的PPARα依赖的脂解机制来释放脂肪酸，从而促进癌细胞HIF-1α/CCL2信号正反馈环路，促进肿瘤增生。

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scResponse: A Rank-Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single-Cell Data

作者：Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao

First published: 23 March 2026

https://doi.org/10.1002/advs.202524397

本研究开发了scResponse工具，可通过高效和量化分析单细胞数据中的细胞亚型和状态，为实现量化分析免疫治疗应答与耐药的潜在机制提供有力工具。

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LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

作者：Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic

First published: 18 July 2025

https://doi.org/10.1002/adbi.202400730

本研究显示促癌基因LIN28B可通过调控IGF2–IGF1R轴诱导血管生成，并促进肿瘤细胞播散，从而推动神经母细胞瘤进展。

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RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1

作者：Gang He, Yilong Wan, Yanbo Zhu, Bo Peng, Shengxiang Shao, Xinyi Zou, Zhenyu Han, Jiaxi Li, Sheng Ju, Xin Tong, Jun Zhao, Hansi Liang, Liuqing Zhang, Jiashi Xiong, Dong Jiang

First published: 12 September 2025

https://doi.org/10.1002/adbi.202500220

本研究显示RRP9在食管鳞状细胞癌（ESCC）可通过增强E2F1对CDK1的转录调控，促进ESCC的恶性进展。

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Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

作者：Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu-Yung Chang, Yao-An Shen, JinMing Yang, Barbara S. Slusher, Ie-Ming Shih, Stephanie Gaillard, Tian-Li Wang

First published: 13 July 2025

https://doi.org/10.1002/adbi.202400738

本研究利用JHU083前药在肿瘤微环境中经蛋白酶切割形成谷氨酰胺拮抗剂DON的机制，同时抑制依赖谷氨酰胺生长的肿瘤细胞和M2型巨噬细胞，打破肿瘤微环境中M1/M2巨噬细胞群体比例，从而达到双重抑制肿瘤生长的目的。

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期刊介绍

Advanced Science 是 Wiley旗舰期刊 Advanced 系列中的一种完全开放获取的跨学科科学期刊，发表材料科学、物理、化学、医学、生命科学、环境科学、工程和社会科学等领域的前沿基础和应用研究。我们的使命是通过开放获取出版，使前沿创新的科学研究具有更广泛的可访问性。Wiley 的 Advanced 系列是全球公认的高影响力期刊系列，传播来自资深和青年研究人员的科学成果，帮助他们实现使命并扩大科学发现的影响力。

Advanced Science最新2024影响因子（JIF）为 14.1，五年平均影响因子为 15.6，JCI 引文指标为1.90，CiteScore 为 18.2。