近日，暨南大学粤港澳中枢神经再生研究院尚春峰及其团队的研究发现麻醉过程中分层全脑神经元网络的进化与重组。相关论文于2026年9月16日发表在《神经科学通报》杂志上。

大脑在不同状态之间波动，例如麻醉和觉醒，这些状态在感觉反应和内在波动方面存在差异。尽管这些已在从分子到脑区域网络的层面上得到深入研究，但全脑神经元相互作用如何产生全局状态以及它们之间转换的潜在机制仍不清楚。在本研究中，研究人员应用快速宽场钙成像，追踪自由游动幼年斑马鱼在觉醒和麻醉期间全脑的神经元活动。在此，研究人员开发了一套方法学流程，用于剖析全脑神经元网络的功能协调，并表征神经元随时间参与功能簇的情况。分析表明，一个动态的局部神经元群体支持稳定的区域间协调和全脑神经元的层级组织，这种组织在麻醉下退化，但随游泳行为恢复。该范式可能适用于解读全局信息处理背后的涌现原理。

附：英文原文

Title: Evolution and Reorganization of the Hierarchical Brain-wide Neuronal Network Through Anesthesia

Author: Chen, Hong-Jing, Zhao, Mei-Ting, Lv, Zhi-Feng, Hao, Jie, Du, Wen-Jie, Shang, Chun-Feng

Issue&Volume: 2026-09-16

Abstract: The brain fluctuates across different states, such as anesthesia and wakefulness, which differ in sensory responses and inherent fluctuations. Although these have been intensively studied at the molecule-to-brain regional network level, the underlying mechanisms by which neuronal interactions across the brain generate global states, and the transitions between them, remain unclear. In the present study, we applied fast wide-field calcium imaging to track neuronal activity across the brains of freely swimming juvenile zebrafish during wakefulness and anesthesia. Herein, we developed a methodological pipeline to dissect the functional coordination of a brain-wide neuronal network and characterize neuronal participation in functional clusters over time. Our analyses showed that a dynamic population of local neurons supported stable inter-regional coordination and the hierarchical organization of neurons across the brain, which deteriorated upon anesthesia, but recovered along with swimming behavior. This paradigm may apply to deciphering the emergent principles underlying global information processing.

DOI: 10.1007/s12264-026-01717-z

Source: https://link.springer.com/article/10.1007/s12264-026-01717-z