高血压的跨器官单细胞分析，这一成果由美国亚利桑那大学
该研究团队对血管紧张素II治疗小鼠、达尔盐敏感大鼠和自发性高血压大鼠的6个器官和组织的高血压和终末器官损伤进行了单细胞分析。该课题组人员确定了与血压和肾损伤相关的基因程序，包括保守的血管平滑肌细胞程序和跨段肾小管程序，以及组织特异性内皮适应和选择器官中细胞类型的协调变化。与人类基因组数据的整合揭示了模型特异性和共享的细胞类型-性状链接。该研究团队优先选择了一个非编码变异（rs28451064），并进行了主题基因组编辑，以证明其在体内对血压和局部基因等位基因特异性调控的影响。他们的研究为高血压研究提供了多模型、跨器官的细胞抵抗。
研究人员表示，高血压是疾病负担和死亡率的主要诱因。
附：英文原文
Title: A cross-organ single-cell analysis of hypertension
Author: Qiongzi Qiu, Yong Liu, Hong Xue, Rajan Pandey, Jing Liu, Lishu He, Pengyuan Liu, Bhavika Therani, Vinod Kumar, Jing Huang, Shima Sadri, Maya Guenther, Kristie Usa, Michael Grzybowski, Mark A. Vanden Avond, Andrew S. Greene, Allen W. CowleyJr., Sridhar Rao, Aron M. Geurts, Mingyu Liang
Issue&Volume: 2026-08-13
Abstract: Hypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II–treated mice, Dahl salt–sensitive rats, and spontaneously hypertensive rats. We identified gene programs associated with blood pressure and renal injury, including a conserved vascular smooth muscle cell program and cross-segment renal tubular programs, along with tissue-specialized endothelial adaptations and coordinated changes across cell types in select organs. Integration with human genomic data revealed model-specific and shared cell type–trait links. We prioritized a noncoding variant (rs28451064) and used genome editing to demonstrate its in vivo effect on blood pressure and allele-specific regulation of local genes. Our study provides a multimodel, cross-organ cellular resource for hypertension research.
DOI: aea6187
Source: https://www.science.org/doi/10.1126/science.aea6187