主题合集简介

Advanced Science 自2014年创刊以来，始终致力于推动跨学科前沿研究，推动基础科学成果向临床与社会实践转化。

为彰显Advanced Science在临床科学领域的持续投入，编辑团队特别推出临床研究专题合集，汇集七篇以患者为中心、兼具严谨性、透明度与创新性的最新研究成果，展现精准医学、临床创新与前沿技术如何切实转化为对患者的疗效。

希望本合集能够激励更多临床医学与转化研究者，将最具突破性的研究成果与我们共同分享。所有收录文章均为开放获取，欢迎扫描文章合集二维码阅读原文：

收录文章

1.Single-Cell Dissection of Tumor-Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang

https://doi.org/10.1002/advs.202521555

2.The Adaptive Physical Activity Study in Stroke (TAPAS): A Feasibility Sequential Multiple Assignment Randomized Trial

Aoife Whiston, Emma Carr, Nathan Cardy, Padraic Rocliffe, Siobhan M. OReilly, Daniel Carter, Mairead ODonoghue, Aine Cronin, James G. Bradley, Mike Butler, Liam Glynn, Jane C. Walsh, Cathal Walsh, Kelley Kidwell, Margaret OConnor, Chris Macey, Lorna Paul, Claire Fitzsimons, Julie Bernhardt, Jon Salsberg, Sara Hayes

https://doi.org/10.1002/advs.202513316

3.Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations

Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker

https://doi.org/10.1002/advs.202503251

4.Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial

Oliver J. Perkin, Sophie E. Davies, Martin Hewison, Kerry S. Jones, Javier T. Gonzalez, James A. Betts, Carl Jenkinson, Mark A. Lindsay, Sarah R. Meadows, Damon A. Parkington, Albert Koulman, Dylan Thompson

https://doi.org/10.1002/advs.202416312

5.Integration of Circulating Tumor DNA and Metabolic Parameters on 18F-Fludeoxyglucose Positron Emission Tomography for Outcome Prediction in Unresectable Locally Advanced Non-Small Cell Lung Cancer

Leilei Wu, Zhenshan Zhang, Chenxue Jiang, Li Li, Xiaojiang Sun, Menglin Bai, Ming Liu, Kangli Xiong, Jinbiao Shang, Jinming Yu, Shuanghu Yuan, Yang Yang, Yaping Xu

https://doi.org/10.1002/advs.202413125

6.The 90-Day Survival Threshold: A Pivotal Determinant of Long-Term Prognosis in HBV-ACLF Patients – Insights from a Prospective Longitudinal Cohort Study

Lanlan Xiao, Jiajia Chen, Shuai Zhao, Wenxin Zhoudi, Keting He, Xiaohan Qian, Fen Zhang, Qiuhong Liu, Tan Li, Danhua Zhu, Xiaoxin Wu, Zhangya Pu, Jianrong Huang, Zhongyang Xie, Xiaowei Xu

https://doi.org/10.1002/advs.202304381

7.AAV-Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness

Jieyu Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Shanzhong Zhang, Yabo Zhai, Yicheng Lu, Xiaoyun Qian, WenXiu Dong, Yinyi Zhou, Ziyu Zhang, Xuehan Yang, Lulu Jiang, Chaorong Yu, Jiancheng Liu, Tian Chen, Lianqiu Wu, Chang Tan, Sijie Sun, Huaien Song, Yilai Shu, Lei Xu, Xia Gao, Huawei Li, Renjie Chai

https://doi.org/10.1002/advs.202306788

期刊介绍

Advanced Science 是 Wiley旗舰期刊 Advanced 系列中的一种完全开放获取的跨学科科学期刊，发表材料科学、物理、化学、医学、生命科学、环境科学、工程和社会科学等领域的前沿基础和应用研究。我们的使命是通过开放获取出版，使前沿创新的科学研究具有更广泛的可访问性。Wiley 的 Advanced 系列是全球公认的高影响力期刊系列，传播来自资深和青年研究人员的科学成果，帮助他们实现使命并扩大科学发现的影响力。

Advanced Science 2025年影响因子为14.1，五年平均影响因子为15.6，期刊引文指标1.74，CiteScore 为 18.1。在 2025年中国科学院院文献情报中心期刊分区表中，Advanced Science 入选综合类期刊一区TOP。

The Advanced Portfolio 最新动态

Advanced Oncology 是一本聚焦肿瘤学全领域的开放获取期刊——从基础癌症生物学到转化医学，再到临床实践，均属于其发表范畴。我们致力于发表突破性癌症研究，探索未知领域，推动科学发现向临床价值转化，为全球癌症研究者和肿瘤学家搭建知识共享平台。Advanced Oncology 现已正式开放投稿，欢迎赐稿！

期刊主页：https://advanced.onlinelibrary.wiley.com/journal/25128647

投稿链接：https://submission.wiley.com/journal/ADON