几十年来，聚合物科学与分子生物学一直沿着相对独立的路径发展，前者关注长链分子如何产生宏观的集体物理性质，后者则主要将 DNA、RNA 和蛋白质视为信息载体和分子机器。

本合集展现了一个越来越清晰的事实: 这两个领域其实密不可分。细胞中的许多功能不仅取决于生物分子的生化特性，也取决于这些分子作为聚合物所表现出的物理行为。与此同时，生命系统也正在不断突破经典聚合物理论的边界，并推动该领域产生新的理论与概念。

由此，两个领域形成了一种真正的双向交流：聚合物科学为理解细胞组织与生命活动提供了定量化的理论语言，而生物学则反过来推动聚合物科学迈向新的研究前沿。

本期封面解读：

在充满活力的细胞世界里，聚合物就像一个个微小的“生命参与者”，彼此互动、协作和组装，共同构建并维持细胞的正常运转。图中的不同角色群体代表聚合物生命科学领域正在兴起的新概念和新方向。这个充满想象力的画面，也体现了聚合物科学与生命科学之间越来越紧密的联系：聚合物科学帮助我们从“物理”的角度理解细胞是如何组织和运作的，而生命科学中的各种复杂现象，也在不断给聚合物科学带来新的问题和灵感，推动我们进一步探索生命世界的奥秘。

了解合集或者文章更多详情，欢迎点击链接或扫描二维码：

https://advanced.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)2198-3844.polymers-in-cellular-function?page=1

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Polymer Concepts in Cellular Function

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PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

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A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

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Dilute but Dense – Reversible Crosslinking Enables Water-Rich (Bio)polymer Condensates

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期刊介绍

Advanced Science 是 Wiley旗舰期刊 Advanced 系列中的一种完全开放获取的跨学科科学期刊，发表材料科学、物理、化学、医学、生命科学、环境科学、工程和社会科学等领域的前沿基础和应用研究。我们的使命是通过开放获取出版，使前沿创新的科学研究具有更广泛的可访问性。Wiley 的 Advanced 系列是全球公认的高影响力期刊系列，传播来自资深和青年研究人员的科学成果，帮助他们实现使命并扩大科学发现的影响力。

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